What are the potential future directions for research and interventions aimed at reducing paracetamol overdose and its consequences?

Summary. Paracetamol toxicity, also known as acetaminophen toxicity, is caused by excessive use or overdose of the analgesic drug paracetamol, also known as ... Acetylcysteine IV (N-acetylcysteine, Parvolex®, NAC) is the treatment of choice. It has near 100% efficacy in preventing paracetamol-induced hepatotoxicity if ... NOTE: This protocol differs from advice on TOXBASE, however the general paracetamol overdose guidance still applies. Please ensure the EDLs/IDLs are given a ... Nov 25, 2024 ... Paper arrow-mass spectrometry (PA-MS) combines sample collection, extraction, separation, enrichment and ionisation onto a single paper strip, achieving rapid, ... Jan 11, 2025 ... Paracetamol is still the almost exclusive cause of liver transplantation related to acute drug overdose, with an average of one case per six million ... Acetaminophen (Tylenol®) toxicity is a common cause of acute liver failure in children and adolescents. Acetaminophen, also known as paracetamol and N ... ... poisoning are listed below. Paracetamol. Paracetamol is a widely used over-the-counter painkiller. Specific signs of paracetamol poisoning include: yellowing ... This systematic review aims to describe the possible factors linked to paracetamol overdoses (intentional and/or accidental) in the adult and child populations ... Mar 31, 2025 ... The Dangers of Paracetamol Overdose. Paracetamol has potentially hepatotoxic properties - that is, it's capable of causing liver injury or ... Mar 7, 2019 ... Overdose with modified-release paracetamol results in a prolonged and unpredictable pattern of paracetamol absorption. Serum paracetamol ...