What are the cultural and societal factors that influence paracetamol use and overdose patterns globally?

This review explores recent estimates in rates of overdose and hepatotoxicity from paracetamol, including mechanism, diagnosis, and treatments. Aims/Objectives/Background Paracetamol overdose is the most common drug overdose in the UK. The standard treatment of Paracetamol toxicity is intravenous N ... Jul 14, 2007 ... Two cases of unintentional paracetamol overdose are presented. Over a one month period these patients presented to an Accident and Emergency ( ... Nov 25, 2024 ... Paper arrow-mass spectrometry (PA-MS) combines sample collection, extraction, separation, enrichment and ionisation onto a single paper strip, achieving rapid, ... In this case report, we present a comatose patient with massive paracetamol overdose who was successfully treated with NAC, hemodialysis and fomepizole. Jan 5, 2022 ... It is safe to use an ingested dose of > 150 mg/kg as the cut-off value for N-acetylcysteine treatment with risk stratification for hepatotoxicity. *Ingested paracetamol = <75mg/kg. Ingested paracetamol = ≥75mg/kg. *Clinical judgement required. • If doubt then assume ≥150mg/kg. Take bloods. No blood tests. Dec 13, 2024 ... New saliva test can rapidly identify paracetamol overdose ... A research team led by the University of Liverpool has developed an innovative new ... Acetylcysteine IV (N-acetylcysteine, Parvolex®, NAC) is the treatment of choice. It has near 100% efficacy in preventing paracetamol-induced hepatotoxicity if ... Aug 26, 2024 ... Acute poisoning: where a patient self-harms by taking a single large dose of paracetamol, or staggered overdose (several ingestions over greater ...