How are adverse drug reactions, including paracetamol overdose, monitored and reported?

Jun 23, 2017 ... Massive paracetamol overdose can result in hepatotoxicity despite early treatment. Paracetamol concentrations were markedly reduced in those receiving ... paracetamol overdose. Pablo Brenera,b, M.D., Mónica Ballardoa, M.D. ... Paracetamol overdose in a preterm neonate. Arch Dis Child Fetal Neonatal Ed. Aug 13, 2024 ... What is paracetamol used for? Paracetamol can be used to treat pain ... Paracetamol overdose. Taking too much paracetamol can be very ... Mar 7, 2019 ... Overdose with modified-release paracetamol results in a prolonged and unpredictable pattern of paracetamol absorption. Serum paracetamol ... Nov 8, 2019 ... Although health professionals may assume that patients know how to use paracetamol, overdose rates continue to rise. Feb 24, 2022 ... The risk of oral paracetamol causing liver toxicity in adults with low bodyweight is recognised in the literature and in patient safety incident ... death from overdose of paracetamol. Lancet 1973;i:66-70. 25 Saunders JB, Wright N, Lewis KO. Predicting outcome of paracetamol poisoning by using 14C ... N-acetylcysteine (NAC) is a safe and effective antidote which if used correctly prevents serious hepatic injury after paracetamol overdose. *Ingested paracetamol = <75mg/kg. Ingested paracetamol = ≥75mg/kg. *Clinical judgement required. • If doubt then assume ≥150mg/kg. Take bloods. No blood tests. The main toxicity following paracetamol poisoning is acute liver injury which results from the formation of a toxic metabolite of paracetamol.