Are there any emerging treatments for paracetamol overdose beyond NAC?

... paracetamol overdose and treatment with N-acetylcysteine (NAC). Patients admitted within seven hours and successfully treated had raised or equivocal GST on ... Jun 23, 2017 ... Massive paracetamol overdose can result in hepatotoxicity despite early treatment. Paracetamol concentrations were markedly reduced in those receiving ... Using data from two prospective cohort studies, we assessed the potential for biomarkers to stratify patients who overdose with paracetamol. NOTE: This protocol differs from advice on TOXBASE, however the general paracetamol overdose guidance still applies. Please ensure the EDLs/IDLs are given a ... Paracetamol is now the most common drug in self‐poisoning, with a high rate of morbidity and mortality. The use, abuse and ways of reducing paracetamol ... ... poisoning are listed below. Paracetamol. Paracetamol is a widely used over-the-counter painkiller. Specific signs of paracetamol poisoning include: yellowing ... Sep 14, 2022 ... Survival rates from a paracetamol overdose are excellent, but only where medical treatment is sought within 2-6 hours after ingestion. If ... *Ingested paracetamol = <75mg/kg. Ingested paracetamol = ≥75mg/kg. *Clinical judgement required. • If doubt then assume ≥150mg/kg. Take bloods. No blood tests. Jan 11, 2025 ... Paracetamol is still the almost exclusive cause of liver transplantation related to acute drug overdose, with an average of one case per six million ... Feb 10, 2022 ... What investigations are important to consider in paracetamol overdose? · Paracetamol level after 4 hours of ingestion · Salicylate level if ...