What are the limitations of drawing conclusions about mechanisms of action from open-label trials?

A5384 is a trial for people who have or might have tuberculous meningitis (TBM). TBM is an infectious disease that causes inflammation of the membranes that ... Open-Label Trial ... An open-label trial is a type of study where both the participants and the investigators are aware of the treatment being provided. It is ... The purpose of this preliminary study is to examine the active music therapy on cognition and neuropsychiatric symptoms in the elderly with mild and moderate ... Apr 8, 2013 ... The study was designed to evaluate the effects of minocycline treatment on markers of neuroinflammation and autism symptomatology in children with autism Donepezil is an effective and safe drug for the long-term symptomatic treatment of mild to moderately severe AD for up to 144 weeks (2.8 years). Apr 25, 2024 ... "Results from this study show that patients with moderate-to-severe atopic dermatitis can strive for both little to no itch and clearer skin.” 1. Jan 4, 2024 ... Participants were randomly assigned to treatment with the glucagon-like peptide 1 receptor agonist semaglutide or the sodium–glucose cotransporter 2 inhibitor ... Effective mood stabilization with a chelated mineral supplement: An open-label trial in bipolar disorder. Citation. Kaplan, B. J., Simpson, J. S. A., Ferre ... Eligibility Requirements. Inclusion Criteria. Subjects must meet all the following criteria for enrollment in the study: - Eastern Cooperative Oncology Group ... Jan 8, 2020 ... The purpose of this research study is to analyze the treatment potential of tofacitinib in patients with sarcoidosis that involves the skin.