What are the challenges in objectively measuring disease-specific symptoms in an open-label trial?

A Phase 3, Multicenter, Randomized, Open-Label Trial to Evaluate the Safety and Efficacy of Epcoritamab + Rituximab and Lenalidomide (R2) compared to ... Oct 30, 2019 ... The study included children aged between 8 and 17 years, with moderate to severe psoriasis, given tofacitinib 5 mg orally twice daily for at least 36 weeks. Study #2024-1042. A Phase II multicenter open-label trial of tagraxofusp (Tag) in combination with venetoclax and azacitidine (Ven/Aza) in adults with ... Jun 17, 2023 ... Treatment with amikacin liposome inhalation suspension (ALIS) improve culture conversion in patients with M abscessus pulmonary disease. The SEISMIC study was an open-label, prospective, randomised study to assess the safety and feasibility of percutaneous myoblast implantation in heart failure ... May 22, 2019 ... The REstart or STop Antithrombotics Randomised Trial (RESTART) was a prospective, randomised, open-label, blinded endpoint, parallel-group trial ... Objective. Irritable bowel syndrome (IBS) is commonly comorbid with generalized anxiety disorder (GAD). We evaluated whether duloxetine would lead to ... Clinical trial for ALT | Non-Alcoholic Fatty Liver Disease | Non Insulin Dependent Diabetes , A Prospective, Randomized, Open Label Trial of Two Doses of ... Mar 4, 2018 ... An exploratory time-varying product-adherence analysis in which adherence was defined as a residual level of 21 mg or less of dapivirine in the ... Carefully designed open-label clinical trials may deliver valuable, high-quality clinical data that can advance the drug development process.