What are the challenges in interpreting patient-reported outcomes in the context of open-label treatment?

Apr 8, 2013 ... The study was designed to evaluate the effects of minocycline treatment on markers of neuroinflammation and autism symptomatology in children with autism This is a first-in-human, Ph 1/2, open-label, multicenter dose escalation and expansion study in advanced solid tumors. Dec 1, 2003 ... ... open-label trial. James Cheng-Chung Wei, Tsai Wen Chan, Huey-Shyan Lin, Feng Huang and Chan-Te Chou. The Journal of Rheumatology December ... Oct 20, 2023 ... Dermavant presents positive results from Phase 4 open-label trial of VTAMA (tapinarof) cream, 1% for the treatment of intertriginous plaque psoriasis in adults. Mar 4, 2025 ... Inclusion Criteria: ... Unresponsive to ≥2 courses of Bacillus Calmette-Guerin (BCG) therapy within the last 12 months. BCG-unresponsive refers to ... An Open-label Trial With Plasma Prekallikrein Oligonucleotide Antisense Therapy To Control Angioedema Attacks In Hereditary Angioedema Patients With Normal C1- ... Jan 8, 2020 ... The purpose of this research study is to analyze the treatment potential of tofacitinib in patients with sarcoidosis that involves the skin. Jun 7, 2021 ... To determine the efficacy of oral immunotherapy (OIT) with raw egg white powder and study its effects on humoral responses in children with persistent egg ... Open-label studies lack the rigor of blinded studies. Since the lack of blinding can introduce significant bias, reserve the use of open-label studies for ... Official Title. A Phase 2/3, Multicenter, Open-label Trial to Evaluate the Long-term Safety, Tolerability, and Efficacy of Sibeprenlimab Administered ...