What are the challenges in defining and measuring patient-centered outcomes in an open-label trial?

Apr 8, 2014 ... Multicentre, Randomised, Open-Label Trial To Compare Efficacy And Tolerance Of Prednisone And IVIG In Patients With CIDP On A One Year Follow Up ... Open-label studies lack the rigor of blinded studies. Since the lack of blinding can introduce significant bias, reserve the use of open-label studies for ... Open-label trial of Sibeprenlimab for treatment of IgAN. Research type. Research Study. Full title. A Phase 2/3, Multicenter, Open-label Trial to Evaluate the ... Donepezil is an effective and safe drug for the long-term symptomatic treatment of mild to moderately severe AD for up to 144 weeks (2.8 years). Study design. CONSERVE was a 1:1 randomized, controlled, open-label, international, multicenter trial at 22 hospitals and cardiology practices in North America, ... Oct 2, 2010 ... Methods. We undertook an open-label randomised phase 3 trial in men with metastatic castration-resistant prostate cancer who had received ... Acthar® Gel (repository corticotropin injection) is FDA-approved for treatment of acute episodes or exacerbation of PsA, but no clinical trials have ... Nov 17, 2020 ... We conducted a prospective, randomized, open-label, multicenter trial of favipiravir for the treatment of COVID-19 at 25 hospitals across Japan. Apr 20, 2023 ... Open-label clinical trials are appropriate when randomization of treatments may be difficult, or if it's important to test long-term effects or safety profiles. This project is being done to test the combination of Loncastuximab Tesirine along with a drug regimen called DA-EPOCH-R for patients with previously ...