How can open-label trials be used to generate hypotheses for future mechanistic studies?

Dec 1, 2003 ... ... open-label trial. James Cheng-Chung Wei, Tsai Wen Chan, Huey-Shyan Lin, Feng Huang and Chan-Te Chou. The Journal of Rheumatology December ... Jun 10, 2011 ... An Open-Label Trial of Risperidone in Children and Adolescents with Severe Mood Dysregulation. Authors: Fernanda Valle Krieger, Gabriel ... An open-label randomised-controlled trial of azathioprine vs. mycophenolate mofetil for the induction of remission in treatment-naive autoimmune hepatitis. MISSION: A Phase 2, Open-Label Trial to Evaluate Safety of Epcoritamab Monotherapy in Subjects with Relapsed or Refractory Diffuse Large B-Cell Lymphoma and ... Jun 7, 2021 ... To determine the efficacy of oral immunotherapy (OIT) with raw egg white powder and study its effects on humoral responses in children with persistent egg ... Perlmutter Cancer Center · Clinical Trials & Research Studies · Phase I open-label trial evaluating BI 1810631 as monotherapy in the treatment of patients with ... Oct 2, 2010 ... Methods. We undertook an open-label randomised phase 3 trial in men with metastatic castration-resistant prostate cancer who had received ... A Phase 3, Multicenter, Randomized, Open-Label Trial to Evaluate the Safety and Efficacy of Epcoritamab + Rituximab and Lenalidomide (R2) compared to ... A5384 is a trial for people who have or might have tuberculous meningitis (TBM). TBM is an infectious disease that causes inflammation of the membranes that ... Conclusions: These data suggest that ligands for the gamma subtype of PPARs may represent a novel therapy for ulcerative colitis. A double blind, placebo- ...