What are potential therapeutic strategies for tinnitus that target hyperpolarization?

The hyperpolarization-enhanced 1H‑imaging modality presented here can allow for hyperpolarized imaging without the need for low‑abundance, low‑sensitivity ... The two general methods of hyperpolarization are dynamic nuclear polarization (DNP) and parahydrogen induced polarization (PHIP). Mar 21, 2012 ... Signaling at PII output synapses is hyperpolarizing in CA1 principal cells (PCs) but depolarizing in dentate gyrus (DG) PCs. While the reversal ... Oct 5, 2024 ... hyperpolarization: A phase where some potassium channels remain open and sodium channels reset. depolarization: Also called the rising phase, ... When the neurotransmitter molecules bind to ligand-gated ion channels on the receiving cell, they may cause depolarization of that cell, causing it to undergo ... Mar 17, 2020 ... Here we reverse the voltage dependence of HCN channels by mutating only two residues located at the interface between the voltage sensor and the pore domain. Sep 1, 2022 ... ... hyperpolarization technique. "This exciting new method is based on an innovative concept. It opens up a whole range of opportunities and ... Apr 11, 2019 ... The use of phase-encoded hyperpolarization allows nanodiamonds to be tagged and distinguished in an MRI based on their spin-orientation alone, ... When the resting membrane potential is made more negative, it increases the minimum stimulus needed to surpass the needed threshold. Neurons naturally become ... Aug 11, 2023 ... We provide convincing evidence for the key role of the h-current in the suprathreshold frequency preference of human L5 cortical neurons.