What are potential therapeutic strategies for multiple sclerosis that target hyperpolarization?

Sep 4, 2012 ... That is, hyperpolarization is an increase in the absolute value of a cell's membrane potential. Thus, any change of membrane voltage in which ... Hyperpolarization refers to a shift in a cell's membrane potential from positive to negative. It suppresses action potentials by increasing the amount of ... Hyperpolarized contrast agents for MRI with long relaxation times. When the nuclear orientation of a material is hyperpolarized by techniques such as dynamic ... Mar 21, 2012 ... Signaling at PII output synapses is hyperpolarizing in CA1 principal cells (PCs) but depolarizing in dentate gyrus (DG) PCs. While the reversal ... Hyperpolarization is said to be the final stage of an action potential after depolarization and repolarization in action potential, respectively. Many diseases ... Mar 16, 2022 ... Accurate simulations show astonishingly rich and unexpected dynamics in SABRE/X-SABRE, which we explain with a combination of perturbation theory and average ... Mar 1, 2003 ... The hyperpolarization-activated, cation nonselective (HCN) gene family encodes the channels that underlie Ih. Here we review the relation ... Jul 5, 2024 ... How to accelerate the acquisition speed and obtain liver images with high spatial resolution: The hyperpolarization level of 13C probe is ... Dec 26, 2023 ... Hyperpolarized 13 C MRI/S allows real-time metabolic changes to be observed non-invasively in living organisms, including cells, tissues, animal models, and ... Apr 4, 2022 ... Apparently the sodium potassium pump restores it following hyperpolarization, but I really can't imagine how it would do that!