What are potential therapeutic strategies for migraine that target hyperpolarization?

Dec 26, 2023 ... Hyperpolarized 13 C MRI/S allows real-time metabolic changes to be observed non-invasively in living organisms, including cells, tissues, animal models, and ... Dec 23, 2020 ... In vitro data suggest that myoendothelial coupling underlies EDH-type dilations as evidenced by blocking experiments as well as simultaneous, merely identical ... Mar 27, 2023 ... Hyperpolarized 13C MRI is an emerging powerful molecular imaging strategy that allows safe, non-radioactive, real time and pathway-specific ... Oct 5, 2024 ... hyperpolarization: A phase where some potassium channels remain open and sodium channels reset. depolarization: Also called the rising phase, ... The crucial point of hyperpolarization is to transfer the polarization from highly polarized systems to nuclear spins. For example, the unpaired electrons in ... Frydman is particularly enthusiastic about is nuclear hyperpolarization [4, 5]. ... hyperpolarization had been known about for 60 years, and for the first 40 of ... Apr 4, 2022 ... Apparently the sodium potassium pump restores it following hyperpolarization, but I really can't imagine how it would do that! movement of a cell's membrane potential to a more negative value (i.e., movement further away from zero). When a neuron is hyperpolarized, it is less likely to ... Sep 5, 2024 ... Hyperpolarization provides the means to overcome the sensitivity limitations of benchtop NMR screenings. Among the different hyperpolarization ... Jul 5, 2024 ... How to accelerate the acquisition speed and obtain liver images with high spatial resolution: The hyperpolarization level of 13C probe is ...