What are potential therapeutic strategies for autoimmune neurological disorders that target hyperpolarization?

Aug 11, 2023 ... We provide convincing evidence for the key role of the h-current in the suprathreshold frequency preference of human L5 cortical neurons. The finding that cAMP facilitates activation of HCN channels by affecting their voltage dependence suggests that the gating mechanism operated by ... Persistent mitochondrial hyperpolarization, increased reactive oxygen intermediate production, and cytoplasmic alkalinization characterize altered IL-10 ... Oct 5, 2024 ... hyperpolarization: A phase where some potassium channels remain open and sodium channels reset. depolarization: Also called the rising phase, ... transitive verb : to produce an increase in potential difference across (a biological membrane) intransitive verb : to undergo or produce an increase in ... Mar 27, 2023 ... Hyperpolarized 13C MRI is an emerging powerful molecular imaging strategy that allows safe, non-radioactive, real time and pathway-specific ... May 8, 2019 ... Hyperpolarization is one way living creatures maintain homestatis, constantly fine-turning their nervous and muscular functions. Hyperpolarisation refers to a group of scientific methods which alter the magnetic properties of materials. This alteration results in large responses in ... Hyperpolarized 13 C magnetic resonance spectroscopic (MRS) imaging has emerged as a complementary metabolic imaging approach. Jan 18, 2016 ... being more sensitive, but the transient character of the hyperpolarization requires a continuous and homogeneous supply of polarized gas ...