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Cetirizine ... Cetirizine is a member of the class of piperazines that is piperazine in which the hydrogens attached to nitrogen are replaced by a (4-chlorophenyl)( ... CETIRIZINE (se TI ra zeen) prevents and treats allergy symptoms, such as red, itchy eyes, sneezing, a runny or stuffy nose, or hives. It works by blocking ... Cetirizine is a second generation antihistamine with a longer duration of action and less sedation than diphenhydramine. Original Prescription Strength - New Look - Same Relief - NDC 50580-726-71 - ZYRTEC - ® ALLERGY - Cetirizine HCl tablets - 10 mg /antihistamine - Indoor & ... May 23, 2013 ... In addition, antihistamines such as fexofenadine (Allegra), cetirizine (Zyrtec), loratadine (Claritin) and diphenhydramine (Benadryl) are very ... Cetirizine lasts longer than diphenhydramine. It lasts 24 hours so it only requires a once daily dose to manage symptoms. When to Use. Treatment of nasal or eye allergies, hives, itching and other allergic symptoms. Table Notes: That said, Zyrtec is a fast-acting drug that starts to work in less than an hour the first time you take it. Cetirizine hydrochloride is also a fast-acting ... Zyrtec (cetirizine) and Claritin (loratadine) are two popular brands. They contain different compounds but appear to be equally effective. Zyrtec (cetirizine) is an over-the-counter medicine that blocks histamine, reducing allergy symptoms like itching and inflammation in pets.