What are the roles of AMPK in the sensory cells of the inner ear?

Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In this review, we will discuss the possible role of AMPK in the beneficial effects of calorie restriction on health and life span. Apr 1, 2016 ... In this review, we provide a comprehensive summary of both indirect and direct AMPK activators and their modes of action in relation to the structure of AMPK. Sep 18, 2015 ... The LKB1/AMPK pathway is involved in the process of tumor invasion and migration, which is an important hallmark of carcinoma progression to higher ... Dec 15, 2023 ... Together, these results demonstrate that AMPK activation by GSK621 elicits traits of immunogenic cell death and promotes a robust immune ... AMPK activity is diminished in adipose tissue of very obese insulin-resistant people, in whom it is associated with increases in oxidative stress and more ... Jul 31, 2024 ... AMPK phosphorylation of β-arrestin-1 Ser330 potentiated PDE4 expression and activity, thereby inhibiting β-AR/cAMP/PKA activation. AMPK switches on catabolic pathways that generate ATP and switches off ATP ... AMPK activation on HSC has not been established. Aim of this study was ... Feb 24, 2023 ... AMPK is a master metabolic sensor that enhances mitochondrial function, insulin signaling and glucose metabolism. Lifestyle interventions that ... Jul 10, 2019 ... The canonical AMP-dependent mechanism of activation requires the upstream kinase LKB1, which was identified genetically to be a tumour ...