What are the potential "unknown unknowns" in AMPK signaling?

The ADP-Glo™ Kinase Assay is a luminescent kinase assay that measures ADP formed from a kinase reaction; ADP is converted into ATP, which is a substrate in a ... Jul 10, 2019 ... The AMP-activated protein kinase (AMPK) acts as a cellular energy sensor. Once switched on by increases in cellular AMP : ATP ratios, ... En réponse à une déplétion énergétique cellulaire, l'AMPK active les voies métaboliques qui produisent de l'énergie (oxydation des acides gras) et inhibe celles ... Mar 17, 2004 ... The enzyme is known as AMP-activated protein kinase, or AMPK. Its activity is regulated by the hormone leptin, which previously was linked ... The ADP-Glo™ Kinase Assay can be used to monitor the activity of virtually any ADP-generating enzyme (e.g., kinase or ATPase) using up to 1mM ATP. Figure 1. Little is known about the function or mechanism of regulation of the remaining AMPK‐related enzymes. ... enzyme (Figure 2, lanes 10–13). It should be noted ... Jun 15, 2012 ... ... AMPK, or in another enzyme that is responsible for activating AMPK, called LKB1, are resistant to becoming cancerous. Patients with Peuta ... Jan 1, 2018 ... ... Enzyme Activation, Enzyme Activators, Enzyme Inhibitors, Fibroblasts, Fluorescent Antibody Technique, Humans, Immunoblotting, Macrolides ... Metformin enhances the PGC-1α expression and mitochondrial biogenesis possibly at least in part via AMPK phosphorylation in the skeletal muscle. The AMP activated protein kinase (AMPK) enzyme complex (consisting of 3 distinct subunits) is major energy sensor whose role is to maintain cellular energy ...