What are the potential therapeutic applications of targeting AMPK in inflammatory and immune disorders?

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1 ... We recently demonstrated that the LKB1 tumour suppressor kinase, ... ... AMPK has been proposed to mediate metformin's glucose lowering effect ... AMPK-independent inhibition of hepatic gluconeogenesis. Likewise, albeit ... Dec 8, 2023 ... As described earlier, AMPK is a potent negative regulator of the inflammatory function of macrophages and promotes the polarisation of ... Apr 1, 2019 ... A compound that is turning out to be one of the major metabolic regulators in the liver, skeletal muscle, fatty acids, and the brain. In this review, we will discuss the possible role of AMPK in the beneficial effects of calorie restriction on health and life span. Jul 19, 2018 ... What if a diabetes medication can improve cardiovascular events? Since patients with type II diabetes are more prone to cardiac events, ... Apr 13, 2017 ... Metabolic stress induces cell death through ROS-induced apoptosis. However, cancer cells can adapt to it by altering the metabolic pathways. Dec 4, 2023 ... Research has shown that FLCN is involved in a lot of different cellular processes and the pathways involved are actually very complex. AMPK Signaling Pathway. The AMP-activated protein kinase (AMPK) signaling pathway is one of the master regulators of cellular metabolism that is found in nearly ... Apr 10, 2017 ... We demonstrate that to permit long-term survival in response to sudden glucose depletion, yeast cells activate lipid-droplet (LD) consumption through micro- ...