How does AMPK influence the differentiation of various cell types?

Evidence here reveals that the rapid growth and proliferation of cancer cells lacking the tumor suppressor LKB1 is due to reduced activity of AMPK. AMPK has been shown to mediate the metabolic effects of hormones such as leptin, ghrelin, adiponectin, glucocorticoids and insulin as well as cannabinoids. Nov 21, 2024 ... AMPK is an enzyme that acts as a universal fuel gauge for plants and animals, revving up when it detects a depletion of the universal fuel. Jun 2, 2016 ... The present study reports that AMPK α1 containing AMPK complexes account for the vast majority of both basal and VEGF-A-stimulated AMPK activity ... May 16, 2017 ... YES the body does have AMP protein kinase which functions in a number of ways on the liver as well as pancreas, heart, skeletal muscle and also ... Nov 14, 2019 ... AMPK acts as an energy regulator and is activated during exercise or other circumstances that use up cellular energy. The AMPK-stimulating AICAR ... AMPK, when activated in the brain's hypothalamus by the hunger hormone ghrelin, increases appetite and consequently weight gain. Whereas AMPK released in the ... Jun 8, 2017 ... AMPK is an enzyme, a protein that performs chemical reactions. AMPK's full name is 5'-AMP-activated protein Kinase. A kinase is an enzyme that ... Feb 1, 2007 ... The PRKAG2 gene provides instructions for making one part (the gamma-2 subunit) of a larger enzyme called AMP-activated protein kinase (AMPK). Our data indicate that metformin induces ALL cell death by triggering ER and proteotoxic stress and simultaneously down-regulating the physiologic UPR response.