How does AMPK contribute to fungal infections?

Dec 15, 2023 ... Together, these results demonstrate that AMPK activation by GSK621 elicits traits of immunogenic cell death and promotes a robust immune ... Apr 13, 2017 ... Metabolic stress induces cell death through ROS-induced apoptosis. However, cancer cells can adapt to it by altering the metabolic pathways. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1 ... We recently demonstrated that the LKB1 tumour suppressor kinase, ... Jul 31, 2024 ... AMPK phosphorylation of β-arrestin-1 Ser330 potentiated PDE4 expression and activity, thereby inhibiting β-AR/cAMP/PKA activation. A key player involved in regulating myocardial metabolism is AMP-activated protein kinase (AMPK), a major regulatory kinase controlling numerous metabolic ... Dec 4, 2023 ... Research has shown that FLCN is involved in a lot of different cellular processes and the pathways involved are actually very complex. An AMPK-derived peptide leads to the activation of AMPK in muscle cells and in adipose tissue and leads to reduced glucose levels in obese mice, but to fat ... Overall, our findings indicate that AMPK plays a vital role in modulating WAT browning in response to thermal, nutritional and pharmacological cues, supporting ... We show that caloric restriction inhibits progressive loss of heart function, even when started after heart failure is already established. PLIN2 phosphorylation is AMPK dependent. (A) Total cell lysates from. Display full size. To identify the kinase(s) behind this lipolysis-induced PLIN2 ...