How can new technologies advance our understanding of AMPK function?

Dec 4, 2023 ... Research has shown that FLCN is involved in a lot of different cellular processes and the pathways involved are actually very complex. Dec 8, 2023 ... As described earlier, AMPK is a potent negative regulator of the inflammatory function of macrophages and promotes the polarisation of ... Jun 15, 2017 ... In response to energy stress, AMPK restores ATP levels by acutely inhibiting ATP-consuming biosynthetic pathways while simultaneously activating ... The phospho-AMPK (Thr172) kit is designed for robust cell-based quantification of AMP-activated protein Kinase modulation when phosphorylated on Threonine 172. Jun 2, 2016 ... The present study reports that AMPK α1 containing AMPK complexes account for the vast majority of both basal and VEGF-A-stimulated AMPK activity ... AMPK activation protects from neuronal dysfunction and vulnerability across nematode, cellular and mouse models of Huntington's disease. Our data indicate that metformin induces ALL cell death by triggering ER and proteotoxic stress and simultaneously down-regulating the physiologic UPR response. AMPK switches on catabolic pathways that generate ATP and switches off ATP ... AMPK activation on HSC has not been established. Aim of this study was ... Overall, our findings indicate that AMPK plays a vital role in modulating WAT browning in response to thermal, nutritional and pharmacological cues, supporting ... Mar 20, 2020 ... Abstract:The cellular energy sensor AMP-activated protein kinase (AMPK) is a metabolic regulator that mediates adaptation to nutritional ...