How can AMPK be targeted for drug development?

Jul 10, 2019 ... The canonical AMP-dependent mechanism of activation requires the upstream kinase LKB1, which was identified genetically to be a tumour ... Aug 22, 2022 ... In this video, Professor Keith Baar explains how the mTOR and AMPK molecular pathways get activated and their role in the interference ... Nov 21, 2024 ... AMPK is an enzyme that acts as a universal fuel gauge for plants and animals, revving up when it detects a depletion of the universal fuel. In this review, we provide a comprehensive summary of both indirect and direct AMPK activators and their modes of action in relation to the structure of AMPK. Sep 10, 2020 ... Metformin treatment of primary hepatocytes and intact murine liver requires AMPK regulation of both RAPTOR and TSC2 to fully inhibit mTORC1, and ... Jul 31, 2024 ... AMPK phosphorylation of β-arrestin-1 Ser330 potentiated PDE4 expression and activity, thereby inhibiting β-AR/cAMP/PKA activation. Nov 14, 2019 ... AMPK acts as an energy regulator and is activated during exercise or other circumstances that use up cellular energy. The AMPK-stimulating AICAR ... AMPK is activated by stimuli like muscle contraction, inflammation, sepsis, metabolic poisoning, exercise, hypoxia, ischemia, heat shock and neuronal necrosis. Jan 15, 2019 ... AMP-activated protein kinase, or AMPK, is known as a master regulator of metabolism. Cells activate AMPK when they are running low on energy, ... AMPK activation positively regulates signaling pathways that replenish cellular ATP supplies, including fatty acid oxidation and autophagy.