Does AMPK affect macrophage polarization?

Sep 10, 2020 ... Metformin treatment of primary hepatocytes and intact murine liver requires AMPK regulation of both RAPTOR and TSC2 to fully inhibit mTORC1, and ... Apr 1, 2019 ... A compound that is turning out to be one of the major metabolic regulators in the liver, skeletal muscle, fatty acids, and the brain. Choline suppresses hepatocellular carcinoma progression by attenuating AMPK/mTOR-mediated autophagy via choline transporter SLC5A7 activation. AMPK is activated by stimuli like muscle contraction, inflammation, sepsis, metabolic poisoning, exercise, hypoxia, ischemia, heat shock and neuronal necrosis. Dec 8, 2021 ... The energy sensor AMP kinase (AMPK) and the master scaffolding protein, AXIN, are two major regulators of biological processes in metazoans. Sep 23, 2014 ... This review describes recent studies examining the molecular mechanisms by which AMPK regulates muscle metabolism. Overexpressed AMPK beta1 localized to specific mammalian subcellular structures that corresponded with the expression pattern of glycogen phosphorylase. Evidence here reveals that the rapid growth and proliferation of cancer cells lacking the tumor suppressor LKB1 is due to reduced activity of AMPK. Studies have shown that increasing your activated protein kinase (AMPK) levels can be an effective way to kickstart your weight management strategy. Feb 1, 2007 ... The PRKAG2 gene provides instructions for making one part (the gamma-2 subunit) of a larger enzyme called AMP-activated protein kinase (AMPK).