What is the role of acylation in signal transduction? What are GTPases and their acylation?

Auto-S-fatty acylated proteins represent a new class of potential drug targets, which often harbor lipid-binding hydrophobic pockets and reactive cysteine ... Dec 21, 2024 ... ... acylation. Here's why this matters. 1️⃣ What is S-acylation? A cellular process that makes proteins function and communicate properly ... eLife assessment. This paper makes a valuable contribution by implicating S-acylation of Cys-130 in recruitment of the inflammasome receptor NLRP3 to the ... The mechanism of this reaction is electrophilic substitution. Acyl halides and anhydrides of carboxylic acids are also commonly used acylating agents to acylate ... Dec 11, 2023 ... Diacetylmorphine is acylated with acetic acid to form heroin. The acylation process involves converting the hydroxyl groups of morphine into ... Mar 19, 2023 ... Question: What is the correct order of events in lab session 1 (see slide 4 and notes page)? Boc installation, neutralization, acylation ... Feb 19, 2024 ... S-acylation, a lipid modification, is emerging as a key regulator of calcium handling proteins, altering their conformation and interactions ... Jul 21, 2022 ... Results · K-Ras(G12S) is an oncogenic driver with GTPase activity · A β-lactone ligand acylates the mutant serine · Optimized β-lactone ligands ... Jun 5, 2015 ... Two enzyme families using phenolic compounds govern the acylation of secondary compounds in vascular plants: BAHD-acyltransferases (BAHD-ATs), ... A: for transmembrane proteins, S-acylation may allow a cytosolic NH2 or COOH terminus or intracellular (IC) loop of a protein to associate with the membrane ...