What are the enantioselectivity and diastereoselectivity in acylation reactions?

Sep 5, 2020 ... Acylation or Friedel Crafts acylation is an example of Electrophilic Aromatic Substitution.The electrophile is CH3CO+ and is generated using ... Aug 22, 2024 ... What is the right way to create a topology for the protein with an acylated amino acid (serine acylated with palmitic acid)? It seems to be complicated for me. by way of acylation with simple achiral acylating agents. Based on the experimental results observed, a transition state (TS) model involving π-interactions ... Auto-S-fatty acylated proteins represent a new class of potential drug targets, which often harbor lipid-binding hydrophobic pockets and reactive cysteine ... Jun 6, 2024 ... Deposition of histone acylations. Among the histone acyl marks, histone acetylation is the best studied. The distribution of histone acetylation ... Nov 13, 2018 ... We know how to use Friedel-Crafts alkylation to attach an alkyl group onto a benzene ring. So now let's learn how to attach an acyl group, ... ... acylation of the amino and alcohol radicals of the starting material. This reference teaches that ease of acylation follows the descending order: primary ... eLife assessment. This paper makes a valuable contribution by implicating S-acylation of Cys-130 in recruitment of the inflammasome receptor NLRP3 to the ... Nov 15, 2023 ... Due to segregation from Golgi localised thioesterase enzymes caused by a nigericin induced breakdown in Golgi trafficking, NLRP3 becomes ... Jul 28, 2021 ... Abstract. The acylated peptide hormone ghrelin impacts a wide range of physiological processes but is most well known for controlling hunger and ...