What are chemical biology approaches to studying acylation? What are genetically encoded tools for manipulating acylation?

This reaction uses the acetyl chloride, CH3COCl, as the acylating agent and the compound called aluminium chloride, AlCl3 as the catalyst. In Friedel-Crafts ... May 4, 2021 ... We previously reported the development of ultra-long-acting fatty diacid acylated insulin analogs (hereafter ultra-long insulin analogs) for oral use. ... acylation: structural information from theory and experiment. Hui Zhu. Dept. of Chemistry and Biochemistry, University of California, Merced, USA. Search ... Aug 18, 2014 ... It is possible to selectively acylate the amine group in aminophenol over the phenolic group by using a weak base (pyridine) at a low temp. Feb 9, 2023 ... ... acylation on human and monkey epithelial cells infected with SARS-CoV-2. Their findings were recently published in the Journal of Lipid ... Apr 25, 2016 ... Acylation is the general term for substitution of acyl group, R-CO- on amino or hydroxyl group of an organic acid whereas acetylation is the ... Sep 18, 2024 ... Acylation is a chemical reaction in which an acyl group (RCO-) is introduced into a molecule. The acyl group contains a carbonyl group (C=O) ... ... acylation of the amino and alcohol radicals of the starting material. This reference teaches that ease of acylation follows the descending order: primary ... And now the aluminum, or this anion, lost its electron, so it goes back to just being straight-up aluminum chloride. It goes back to just being straight-up ... by way of acylation with simple achiral acylating agents. Based on the experimental results observed, a transition state (TS) model involving π-interactions ...