How does acylation affect the stability of a molecule? What is the role of acylation in detoxification processes in the body?

Oct 10, 2021 ... A new study published in Developmental Cell investigates S-acylation of the SARS-CoV-2 S protein. by way of acylation with simple achiral acylating agents. Based on the experimental results observed, a transition state (TS) model involving π-interactions ... May 4, 2021 ... We previously reported the development of ultra-long-acting fatty diacid acylated insulin analogs (hereafter ultra-long insulin analogs) for oral use. What is S-acylation? S-acylation is the post-translational addition of fatty acids to protein cysteine residues though a thioester bond. Importantly, and unlike ... Our results from using mass spectrometry (MS) show that influenza B virus HA possessing two cytoplasmic cysteines contains palmitate. In combination with one of the strong acylating agents, the nucleophilic amines with no NH bonds undergo a fast acylation reaction that gives a cationic acyl ... Friedel-Crafts Alkylation · Formation of a positively charged benzene ring. Two electrons are removed from the delocalised electron ring in benzene and used to ... ... acylation, allows Gai proteins to focus near the receptor and transmit its message properly in the heart cell. They found decreased amounts of these ... A novel bioluminescence-based method to investigate uptake of bile acids in living cells. Am. J. Physiol. Gastrointest. Liver Physiol. 2018; 315:G529-G537 Request PDF | Uncovering Key Structural Features of an Enantioselective Peptide-Catalyzed Acylation Utilizing Advanced NMR Techniques | We report on a ...