How do mutations affect our lifespan? What are the genetic determinants of longevity?

Nov 13, 2023 ... MPNs are blood cancers caused by the overproduction of blood cells in the bone marrow. Mutations in the gene controlling JAK2 protein production ... The Fragile X mutation is a type of genetic mutation called a repeat expansion. This repeat expansion occurs on the FMR1 gene, on the long arm of the X ... The two genes could be the same mutation, or you could have two different ones. The specific mutations and combination you have is known as your 'genotype'. Jan 22, 2025 ... A mutation in the gene that codes for the EGFR protein can make cells grow too much, which can cause cancer. ... mutations. The major example of ... Oct 13, 2023 ... Hemophilia is typically caused by mutations in the genes that provide instructions for making proteins needed for proper blood clotting. Myeloproliferative neoplasms (MPNs) are blood disorders caused by an excessive production of blood cells in the body. There are a number of gene mutations, ... May 5, 2023 ... Cancer is caused by genetic mutations that make the cells multiply at an uncontrolled rate. There are many factors that cause these mutations. Mar 5, 2021 ... Mutations have many possible causes. Some mutations seem to happen spontaneously without any outside influence. They can occur when mistakes are made during ... While most DNA replicates with fairly high fidelity, mistakes do happen, with polymerase enzymes sometimes inserting the wrong nucleotide or too many or too ... Jun 15, 2021 ... ... causes the disease ... Sickle cell disease (SCD) is a genetic disorder caused by a mutation in both copies of a person's HBB gene.