What are the emerging technologies in drug discovery and development involving mammalian cells?

The in vitro mammalian cell gene mutation test can be used to detect gene mutations induced by chemical substances. In this test, the used genetic endpoints ... High frequency retrotransposition in cultured mammalian cells. Cell. 1996 Nov 29;87(5):917-27. doi: 10.1016/s0092-8674(00)81998-4. To ensure genome stability, mammalian cells employ several DNA repair pathways. Nonhomologous DNA end joining (NHEJ) is the DNA repair process that fixes ... We offer complete solutions for cell line and process development, late phase activities, clinical and commercial manufacturing for a wide variety of ... Cell-cell transfer of mRNA and its role in mammalian cell physiology. mRNA in tunneling nanotube. HER2 mRNA (red) visualized by single-molecule FISH in ... Starvation induces diffusion hindrance at the nanoscale in mammalian cells. S. Sareen, A. Zgorzelska, K. Kwapiszewska and R. Hołyst, Nanoscale, 2025, 17, 378 ... Mammalian cells are gaining popularity in expressing protein as there is more flexibility in pursuing this route. However, unlike plant cells or yeast, ... May 17, 2024 ... Here, we measured transport and metabolism of individual lipid species in mammalian cells using time-resolved fluorescence imaging of bifunctional lipid probes. Introduction: Biomedical experiments in microgravity provide an insight into the fundamental mechanisms of living cells. Not only astronauts benefit from ... Sep 27, 2022 ... Here, we report progress on a large-scale synthetic genomics effort to reestablish EAA biosynthetic functionality in mammalian cells.