What are the current challenges in toxicology research using mammalian cells?

Abstract. DNA-calcium phosphate co-precipitates arise spontaneously in supersaturated solutions. Highly effective precipitates for transfection purposes, ... Apr 19, 2009 ... We report that 6–30% of cap-selected mouse and human RNA transcripts initiate within repetitive elements. Jun 23, 2021 ... What is mammalian cell culture? Mammalian cell culture is the technique of growing animal cells outside of their original tissue but in a growth ... These results demonstrate that gene expression in mammalian cells is subject to large, intrinsically random fluctuations and raise questions about how cells ... Cell-cell transfer of mRNA and its role in mammalian cell physiology. mRNA in tunneling nanotube. HER2 mRNA (red) visualized by single-molecule FISH in ... We discuss the progress in direct and indirect imaging of differentially linked ubiquitin chains in fixed and living cells using confocal fluorescence ... RNA modifications are involved in many aspects of biological functions. RNA modification controls cell fate transition in the mammalian embryonic stem cells ... This article describes how mammalian cells are derived, their utility, and the processes that harness their full potential. An efficient DNA damage response is critical for maintaining the integrity of the mammalian genome, and ensuring the accurate transfer of genetic ... Sep 27, 2022 ... Here, we report progress on a large-scale synthetic genomics effort to reestablish EAA biosynthetic functionality in mammalian cells.