How can understanding the molecular mechanisms in cancer cells lead to new therapies?

RNA modifications are involved in many aspects of biological functions. RNA modification controls cell fate transition in the mammalian embryonic stem cells ... High frequency retrotransposition in cultured mammalian cells. Cell. 1996 Nov 29;87(5):917-27. doi: 10.1016/s0092-8674(00)81998-4. To ensure genome stability, mammalian cells employ several DNA repair pathways. Nonhomologous DNA end joining (NHEJ) is the DNA repair process that fixes ... This article describes how mammalian cells are derived, their utility, and the processes that harness their full potential. Our Gibco, Thermo Scientific Nunc, and Invitrogen cell culture products help you to achieve reproducible results and successful research outcomes—every day ... Mar 25, 2014 ... Plasmid transfection into mammalian cells is fairly straightforward and the resultant cells can either express the plasmid DNA transiently ( ... Sep 27, 2022 ... Here, we report progress on a large-scale synthetic genomics effort to reestablish EAA biosynthetic functionality in mammalian cells. We have wild type and several glyco-engineered HEK293s strains growing in serum free suspension to produce different glycoforms of therapeutic proteins. We offer complete solutions for cell line and process development, late phase activities, clinical and commercial manufacturing for a wide variety of ... These results demonstrate that gene expression in mammalian cells is subject to large, intrinsically random fluctuations and raise questions about how cells ...