What are the potential off-target effects of B cell-targeted therapies?

Mar 10, 2021 ... ... switching. Neuritin reduced differentiation of mouse and human GC B cells into plasma cells, downregulated BLIMP-1, and upregulated BCL6. Oct 5, 2022 ... This article provides an overview of the mechanisms by which the different human antibody subclasses regulate immunity. Thus, CD40L/CD40 and MHC class II/T cell receptor (TCR) interactions are essential for peripheral B cell tolerance. The decreased numbers of CD4+ regulatory T ( ... The role of the CD19/CD21 complex in B cell processing and presentation of complement-tagged antigens. Feb 13, 2015 ... The immune system can remember a previously experienced pathogen and can evoke an enhanced response to reinfection that depends on memory lymphocyte ... Controversies Conference on Therapies Targeting B Cells in Immune-Mediated Kidney Diseases ... The goal of this KDIGO conference is to review the efficacy and ... CD20 is a B cell-specific membrane protein and represents an attractive target for therapeutic antibodies. Despite widespread usage of anti-CD20 antibodies ... As a result, VA expanded chronic lymphocytic leukemia to include all chronic B-cell leukemias as related to exposure to Agent Orange or other herbicides during ... Background Evidence suggests that monoclonal B-cell lymphocytosis precedes all chronic lymphocytic leukemia cases, although the molecular mechanisms ... Jul 23, 2019 ... ( A ) Histogram and graph displaying TGFβRI expression and MFI of TGFβR1 staining in HEL-specific cells from spleens, pLNs, mLNs, and PPs of ...