What are the potential benefits and risks of manipulating B cell responses in the context of aging?

DLBCL is a common type of fast growing (high grade) NHL. Lymphoma develops when white blood cells called lymphocytes grow out of control. What the effector cells do is, they turn into antibody-- they turn into these effector B cells-- or sometimes they're called plasma cells. They're going to turn ... Aug 19, 2024 ... This trial represents the largest randomized study of radiotherapy in PMBCL to date. Despite encountering challenges due to unexpectedly good ... While B-cells produce antibodies to fight infection, T-cells protect people from getting infected by destroying cancerous and infected cells. B-cells are also ... Apr 3, 2017 ... These immune tolerance mechanisms function at various stages of B cell development. Central tolerance refers to the regulatory mechanisms that ... Feb 21, 2025 ... A framework, Mal-ID (machine learning for immunological diagnosis), to interpret the variable sequences of B and T cell receptors (BCRs and TCRs) from human ... Arthur H. and Isabel Bunker Professor of Medicine (Hematology) and Professor of Immunobiology; Director, Center of Molecular and Cellular Oncology; Chief, ... This type of activation produces memory and plasma B cells. Naïve B cells bind to soluble or membrane bound antigens and internalize the antigen. The B cell ... T cells are responsible for cell-mediated immunity. B cells, which mature in the bone marrow, are responsible for antibody-mediated immunity. Apr 12, 2024 ... Current WHO B cell lymphoma classification features the following major updates (Int J Lab Hematol 2017;39:14): Newly defined high grade B cell lymphomas.