What are the mechanisms of B cell tolerance?

Rate of New Cases and Deaths per 100,000: The rate of new cases of diffuse large B-cell lymphoma was 5.6 per 100,000 men and women per year. The death rate was ... Jan 17, 2025 ... Cutaneous B-cell lymphoma is a cancer that starts in the white blood cells and attacks the skin. It often causes a lump or group of lumps on the skin. CD20 is a B cell-specific membrane protein and represents an attractive target for therapeutic antibodies. Despite widespread usage of anti-CD20 antibodies ... Get Personalized Information & Support ... B-cell prolymphocytic leukemia (B-PLL) is a very rare and typically aggressive malignancy (cancer) characterized by the ... T cells are responsible for cell-mediated immunity. B cells, which mature in the bone marrow, are responsible for antibody-mediated immunity. Screening for common variable immunodeficiency and hyper-IgM syndromes. Assessing B-cell subset reconstitution after stem cell or bone marrow transplant. While B-cells produce antibodies to fight infection, T-cells protect people from getting infected by destroying cancerous and infected cells. B-cells are also ... When a naïve or memory B cell is activated by an antigen, it proliferates and differentiates into an antibody-secreting effector cell, known as a plasmablast or ... What the effector cells do is, they turn into antibody-- they turn into these effector B cells-- or sometimes they're called plasma cells. They're going to turn ... ... cells, B cells, and plasma cells secreting pathogenic autoantibodies will be illuminated. The importance of cognate B cell help to autoreactive T cells will ...