What are the key transcription factors involved in B cell development?

... cells, B cells, and plasma cells secreting pathogenic autoantibodies will be illuminated. The importance of cognate B cell help to autoreactive T cells will ... Get Personalized Information & Support ... B-cell prolymphocytic leukemia (B-PLL) is a very rare and typically aggressive malignancy (cancer) characterized by the ... Không có mô tả T cells are responsible for cell-mediated immunity. B cells, which mature in the bone marrow, are responsible for antibody-mediated immunity. Mar 10, 2021 ... ... switching. Neuritin reduced differentiation of mouse and human GC B cells into plasma cells, downregulated BLIMP-1, and upregulated BCL6. Feb 7, 2025 ... Researchers explore the role of B cells in non-lymphoid tissues, revealing new insights into infections, cancer, potential therapeutic breakthroughs. When a naïve or memory B cell is activated by an antigen, it proliferates and differentiates into an antibody-secreting effector cell, known as a plasmablast or ... Feb 15, 2024 ... About 1 out of 5 lymphomas in the United States is a follicular lymphoma. This is usually a slow-growing (indolent) lymphoma, although some follicular ... This type of activation produces memory and plasma B cells. Naïve B cells bind to soluble or membrane bound antigens and internalize the antigen. The B cell ... Newborns with congenital athymia may develop autoreactive oligoclonal T-cell expansion resulting in a constellation of symptoms (e.g erythroderma and ...