How do malignant plasma cells contribute to the pathology of multiple myeloma?

Sep 7, 2017 ... The US Food and Drug Administration granted regular approval to tisagenlecleucel (KYMRIAH, Novartis Pharmaceuticals Corp.) for the treatment of patients up to ... Apr 12, 2024 ... Current WHO B cell lymphoma classification features the following major updates (Int J Lab Hematol 2017;39:14): Newly defined high grade B cell lymphomas. Aug 19, 2024 ... This trial represents the largest randomized study of radiotherapy in PMBCL to date. Despite encountering challenges due to unexpectedly good ... The finding gives oncologists a new target for developing immunotherapies: double negative memory B cells, so-called because they are negative for two markers. While B-cells produce antibodies to fight infection, T-cells protect people from getting infected by destroying cancerous and infected cells. B-cells are also ... What is primary mediastinal large B-cell lymphoma? Primary mediastinal large B-cell lymphoma (PMBCL) is a type of non-Hodgkin lymphoma (NHL). It is sometimes ... This type of activation produces memory and plasma B cells. Naïve B cells bind to soluble or membrane bound antigens and internalize the antigen. The B cell ... Arthur H. and Isabel Bunker Professor of Medicine (Hematology) and Professor of Immunobiology; Director, Center of Molecular and Cellular Oncology; Chief, ... In the article “α4-integrin deficiency in B cells does not affect disease in a T-cell–mediated EAE disease model" by Hussain et al., first published online ... DLBCL is a common type of fast growing (high grade) NHL. Lymphoma develops when white blood cells called lymphocytes grow out of control.