How can B cell responses be modulated to treat inflammatory diseases of the gut?

... cells, B cells, and plasma cells secreting pathogenic autoantibodies will be illuminated. The importance of cognate B cell help to autoreactive T cells will ... The role of the CD19/CD21 complex in B cell processing and presentation of complement-tagged antigens. Dec 15, 2020 ... BCDTs such as those targeting CD20, CD19 and BAFF are now used to treat autoimmune diseases, including systemic lupus erythematosus and multiple sclerosis. Nov 12, 2024 ... Prof.dr. J.H. Veelken Prof.dr. M.A. Navarrete Summary B cells are a type of white blood cell that produce antibodies to fight infections. The finding gives oncologists a new target for developing immunotherapies: double negative memory B cells, so-called because they are negative for two markers. Background Evidence suggests that monoclonal B-cell lymphocytosis precedes all chronic lymphocytic leukemia cases, although the molecular mechanisms ... The B Cells have the ability to transform into plasmocytes and are responsible for producing antibodies (Abs). Thus, humoral immunity depends on the B Cells ... Newborns with congenital athymia may develop autoreactive oligoclonal T-cell expansion resulting in a constellation of symptoms (e.g erythroderma and ... Epigenetics is the study of changes in gene activity that are heritable but not caused by changes in the DNA sequence. By modulating gene activities, ... T cells are responsible for cell-mediated immunity. B cells, which mature in the bone marrow, are responsible for antibody-mediated immunity.