What are the challenges in translating in vitro findings of new antimicrobial agents to in vivo efficacy in humans?

The Cica-beta test could be an efficient test for the detection of ESBL-producing pathogens in urine. By providing immediate information about ESBLs, it might ... In this study one type of ESBL-producing strain was identified. In. Colombia, higher percentages of ESBL-producing K. pneumoniaeand E. coli strains have been ... CF therapy may represent an effective alternative to carbapenem treatment for patients with ESBL-EC bacteremia for empirical and definitive therapy in adult ... In this study we aimed to investigate in vitro activity of meropenem, ciprofloxacine and amikacin against ESBL-producing and non-producing blood isolates. The aim of this study is to detect ESBL-producing Enterobacteriaceae by using rapid detection tests such as combined disk diffusion, ESBL E-test strips. Not much information on ESBL producing organisms causing infection is available from the south west coastal region. An effort was therefore made to study the ... The data we presented in our study showed that the treatment of UTI in Turkiye in 2016 incurred cost in excess of 50 million TL. ESBL-positive E. coli detection ... Apr 10, 2016 ... Hence the present study was performed to know the susceptibility pattern of K pneumoniae to various antibiotic groups and prevalence of ESBL. The objective of this study was to quantify the amount of patient-to-patient transmission among patients who acquire an ESBL-producing E coli infection using ... Jun 27, 2005 ... ... ESBL-EK cultures during the study period. For a given patient, the first ESBL-EK infection was included, and subsequent infections were ...