How do autoimmune diseases disrupt the normal immune regulation of melanocytes, leading to conditions like vitiligo?

Oct 12, 2017 ... ... informative for mapping genetic variants associated with skin pigmentation. ... causes the high pigment-1 mutant phenotype. Theor. Appl ... ... pigmentation, complexion, or skin shade or tone. Thus, color discrimination ... information about an applicant's race separate from the application. In ... Some types of EDS can also cause severe fragility of the skin, blood vessels, abdominal organs, eyes, gums, and bones. What are the types of EDS? The current ... Do not use. BENLYSTA if the product exhibits discoloration or particulate matter. Instruct the patient not to use the BENLYSTA autoinjector or prefilled syringe ... Mar 15, 2023 ... Dark pigmentation of the skin. Recurring ear infections; Recurring skin infections; High cholesterol; Slow heart rate; Lameness; Lack of ... Nov 4, 2024 ... Informational Videos · Pediatric ... OA mainly affects the eyes, with normal or near-normal skin and hair color. WHAT CAUSES ALBINISM? Apr 23, 2025 ... From vein disease to sun damage, skin discoloration on legs has many causes. Uncover what's behind your symptoms and effective solutions for ... ▻ Repeated exposure may cause a greenish discoloration of the skin ... low future exposure can cause itching and a skin rash. ▻ Copper may affect ... The OCA2 gene impacts skin pigmentation by regulating melanosome pH (73,74), and mutations in this gene cause oculocutaneous albinism type II (OCA2) (75). HERC2 ... Apr 4, 2024 ... Without treatment, they may cause ulcers, bleeding, and skin discoloration. ... See additional information. Logo for WebMD.