



What role does histamine play in the gut, and how might increased sensitivity lead to digestive issues?
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what causes ibs to start Informational
- Are there any underlying conditions that can lead to fat malabsorption and potentially trigger IBS? Can changes in the composition or function of the gut virome (the collection of viruses in the gut) contribute to the start of IBS?
- How might altered levels contribute to IBS? Can changes in the gut's response to leptin, a satiety hormone, contribute to the onset of IBS symptoms?
- How might its dysregulation be involved in IBS? Can changes in the gut's response to gastrin-releasing peptide (GRP) contribute to the onset of IBS symptoms by affecting motility and secretion?
- How might temperature affect gut motility and sensitivity?
- How might their deficiency or overproduction be involved in IBS? Can alterations in the gut's neuroimmune interactions contribute to the onset of IBS symptoms by affecting inflammation and visceral sensitivity?
- What regulates tight junctions?
- How might their altered function contribute to IBS? Can alterations in the gut's production of dendritic cells contribute to the onset of IBS symptoms by affecting antigen presentation and immune responses?
- What are cytokines?
- What is the role of the lymphatic system in the gut?
- Are there any dietary or lifestyle factors that can support a healthy gut mucus layer? Can problems with the migrating motor complex (MMC), the cyclical pattern of electrical activity in the gut, contribute to the start of IBS?
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